Fig. 9

CINMs for PET-, SPECT- and PAI-guided PTT. A Synthetic procedures and mechanisms of BP@Cu@PEG-RGD NSs. B PET images of tumor-bearing mice treated with saline or NSs after 2 weeks. C Comparison of PET images with experimentally measured tumor volumes. Reproduced with permission [190]. Copyright 2020, Springer Nature. D Synthetic procedures of ^99mTc-M-CuS-PEG. E SPECT/CT images of tumor-bearing mice treated with ^99mTc-4T1-M-CuS-PEG or ^99mTc-CT26-M-CuS-PEG. Reproduced with permission [191]. Copyright 2021, Wiley-VCH. F Synthetic procedures and mechanisms of SCP-CS. G PAIs and corresponding signal intensity of tumor-bearing mice treated with SCP-CS and SCP at 808 nm and 1064 nm. Reproduced with permission [192]. Copyright 2021, Elsevier. H Synthetic procedures and activation mechanisms of Fe-Cu@PANI. I PAIs with different GSH concentrations. J Linear relationship between PA intensity and GSH concentration. K PAIs and (L) corresponding signal intensity of tumor-bearing mice treated with Fe-Cu@PANI. Reproduced with permission [193]. Copyright 2021, American Association for the Advancement of Science (AAAS)