Table 1 HA-based bioinks for different tissue-engineering applications
From: 3D printed scaffolds based on hyaluronic acid bioinks for tissue engineering: a review
Material | Cells/Active substance | Crosslinking | Applications | In vitro /In vivo | Bioprinting technology | Ref |
|---|---|---|---|---|---|---|
GelMA/HAMA | Chondrocytes | / | Cartilage | both | DLP printing | [58] |
HA-TYR | Chondrocytes | Enzyme crosslinking | Cartilage | in vivo | Extrusion-based bioprinting | [59] |
HA | rhbmp-2, Kartogenin, TCP | Chemical crosslinking | Cartilage | in vivo | Extrusion-based bioprinting | [60] |
Gel/HA/PVA | DX | Physical crosslinking | Bone | in vivo | Extrusion-based bioprinting | [61] |
Gel/HA/HyA | Mscs | Chemical crosslinking | Bone | in vitro | Extrusion-based bioprinting | [62] |
HA/PLL | c(RGDfC)/β-TCP | Physical crosslinking | Bone | in vitro | Extrusion-based bioprinting | [63] |
PCL-PU/HAMA | C2C12 | Chemical crosslinking | Skeleton muscle | in vitro | Extrusion-based bioprinting | [64] |
HACA/Alg | C2C12 | Combining multiple crosslinking | Skeleton muscle | in vitro | Extrusion-based bioprinting | [51] |
HAVS/HASH/HBC | Nscs | Combining multiple crosslinking | Neural tissue | both | Extrusion-based bioprinting | [65] |
PVA/HA-PBA | Neural precursor cells | Chemical crosslinking | Neural tissue | in vitro | Extrusion-based bioprinting | [66] |
GelMA/HAMA | Human dermal fibroblasts | Chemical crosslinking | Skin | in vitro | LAB bioprinting | [67] |
HA/PCL/45S5 Bioglass | hDPSCS | / | Dental materials | in vitro | Extrusion-based bioprinting | [68] |
RSFMA/HAMA | hDPSCS | Chemical crosslinking | Dental materials | in vitro | Extrusion-based bioprinting | [69] |
Collagen/HA | Patient-derived cancer cells | Physical crosslinking | Disease models | in vitro | Extrusion-based bioprinting | [70] |
HAMA | Islet cells/Pancreatic ECM | Combining multiple crosslinking | Disease models | Both | Extrusion-based bioprinting | [71] |
Chitosan/HA | Vancomycin | Chemical crosslinking | Drug delivery | in vitro | Extrusion-based bioprinting | [72] |
HA | HUVECs/Fibrinogen | / | Vascularized tissue | in vitro | Extrusion-based bioprinting | [73] |
Gel/HA/Elastin | Ocular epithelial cells | Chemical crosslinking | Corneal tissue | Both | Extrusion-based bioprinting | [74] |