Fig. 8

HA for disease models. A Immersion bioprinting of tumor tissue-like organs increases the throughput of multi-well plate screening for chemotherapy [206]. Copyright 2021, the Authors. Licensee MDPI, Basel, Switzerland. Based on Creative Commons Attribution License (CC BY). B 3D bioprinted breast cancer–adipose tissue model. (I) Printed gel spheroids with 1 wt% high-molecular weight HA to ensure a uniform HA distribution. (II) The printed HA spheroids were subjected to lipogenic differentiation for 21 days with good survival of seed cells [207]. Copyright 2021, the Authors. Licensee MDPI, Basel, Switzerland. Based on Creative Commons Attribution License (CC BY) C. 3D bioprinted glioblastoma models consisting of HAMA and (GelMA) with brain tumor-specific ECM-derived bioinks were created for four different tumors [208]. Copyright 2021, Wiley–VCH GmbH. License Number:5620830466879. D Two-photon polymerization technology for fabrication of 3D printed microscopic scaffolds to form miniature tumor tissue and mimic metastatic cancer models. Reprinted (adapted) with permission from [209]. Copyright 2022, American Chemical Society