Fig. 8
Combination therapy with immunotherapy for bone tumors. A Schematic diagram of the therapeutic mechanisms of NPER/BO-PDT. B ER targeting of NPER/BO-PDT in MNNG/HOS cells at different times. Scale bar: 10 μm. C The percentages of mature DCs in tumor-draining lymph nodes and percentages of CD8 T cells and CD4 T cells in tumor tissues of K7M2 tumor-bearing mice after different treatments (*p < 0.05 and **p < 0.01). Reproduced with permission [105]. Copyright 2022, Wiley-VCH. D Schematic illustration of the synthetic and therapeutic mechanisms of Oxa(IV)@ZnPc@M for chemo-photodynamic therapy of primary and bone metastatic breast cancer. Reproduced with permission [106]. Copyright 2021, Springer Nature. E Schematic diagram of the synthetic and therapeutic mechanisms of ZnPP@MSN-RGDyK for NSCLC-SM. Reproduced with permission [107]. Copyright 2022, Wiley-VCH