Fig. 6
Photothermal bone scaffolds for the treatment of bone infections. A Schematic diagram of the mechanism of BPs@HA composite coating to promote fracture healing. B Representative photographs of the surgical site (the implant was inserted into the cancellous bone of the tibia just below the tibial plateau) and colonies of bacteria from the implant surface. C Micro-CT 3D reconstruction of femur fracture sites after treatment with wire (stainless Kirschner wire), HA-wire, and BPs@HA-wire. Reproduced with permission [73]. Copyright 2022, American Chemical Society. D Transwell migration assay of Schwann cells treated with GelMA, GB (GelMA loaded with BP), GBM hydrogel. Scale bar: 100 μm. E Immunostaining of PC12 cells cultured in Schwann cells conditioned medium on day 5 (GBM hydrogel effectively promoted neurite outgrowth). F Antibacterial capacity of different hydrogels with and without laser irradiation. Micro-CT 3D reconstruction images G and colony number H of S. aureus-infected skull defects treated with different hydrogels and periodic 808 nm (1 W/cm2) laser irradiation. I NGF and J CGRP immunofluorescence staining images of skull tissue. Scale bar: 500 μm (top), 200μm (bottom). Reproduced with permission [75]. Copyright 2023, Wiley-VCH