Fig. 6
From: Post-insertion technique to introduce targeting moieties in milk exosomes for targeted drug delivery
Therapeutic effect of Dox@mExo-FA in HCT116 tumor-bearing mouse. (A) Experimental scheme for assessing in vivo antitumor effect of Dox@mExo-FA. (B-C) Tumor growth curves for 16 days after injection of each group (n = 5–8 for each group; black circle: PBS; blue circle: mExo-FA; white circle: free Dox; green circle: Dox@mExo; red circle: Dox@mExo-FA). The administration dose was adjusted to 3 mg/kg of free Dox concentration. (D-E) A TUNEL assay for confirming apoptotic cells in tumor tissues three days after final treatment (D) and a quantified graph indicating a TUNEL-positive area (E). Scale bar: 200 μm. (F) Tumor weight measured after three days of the last injection of all groups. One-way ANOVA with Tukey’s post-hoc multiple comparison was carried out for statistical analysis. n.s.: not significant, *P < 0.05, **P < 0.01, ***P < 0.001