Fig. 5

Schematic illustrations of IL4-MOF@CaP nanosystem for enhanced bone regeneration (a), Schematic illustration of the synthesis and characterization of IL4-MOF@CaP (b), In vivo spatiotemporal evaluation of the M2 macrophage polarization around the Col or IL4-MOF@CaP/Col scaffolds [blue, green and red respectively present DAPI, CD206, and CD68 Staining] (c), Schematic illustration of the accurate and proactive immunomodulation properties of IL-4-MOF@CaP, which was beneficial for angiogenesis and osteogenesis (d) [129]