Fig. 8
From: Application of advanced biomaterials in photothermal therapy for malignant bone tumors
Schematic diagram of “first kill and then regenerate” by CPT. A Schematic illustration of a cranial defect in a rat with a multifunctional scaffold implanted by PTT ablation of a tumor in a nude rat, local chemotherapy, and reconstruction. B Live and dead images of rBMSCs were cultured on different scaffolds on day 3. Scale bars: 200 µm and 100 µm. C Viability of rBMSCs on days 3 and 7. D The proliferation of rBMSCs on scaffolds in the 7 days. E Temperature distribution of tumor tissue implanted with scaffolds in vivo. F Effect of NIR laser power on the temperature increase of BDPTP scaffolds. G Effect of temperature increase of different scaffolds irradiated by NIR laser. For panels C and D, *p < 0.05. Abbreviations: mesenchymal stem cell (MSC), black phosphorus (BP), tricalcium phosphate (TCP), poly (lactic-co-glycolic acid (PLGA), TCP/PLGA (TP), P24/TCP/PLGA (PTP), DOX/P24/TCP/PLGA (DPTP), BP/P24/TCP/PLGA (BPTP), DOX/P24/BP/TCP/PLGA (BDPTP). Reproduced with permission from Ref. [187]