Fig. 2

A Schematic illustration of the fabrication for theranostic GNP and the antitumor mechanisms in the tumor cell. B The fluorescence signal of NP and green fluorescent protein-labeled A549 cells in the frozen section of the tumor 48 h after administration of NP. Scale bar: 100 µm and 50 µm. C The bioluminescence (labeled A549 cells) and fluorescence (NP in blue) images of the mice with spinal metastasis at 0, 3, 8, and 24 h after injection. D TUNEL fluorescence images described apoptosis in tumor slices. Abbreviations: Alpelisib (BYL719), tetraethyl orthosilicate (TEOS), Cetyltrimethyl Ammonium Bromide (CTAB), indocyanine green (ICG), polyethylene glycol (PEG), poly acrylic acid (PAA), BYL719@Au@MOF-BAM, BYL719@Au@MOF@MS-ICG (BAMM), BYL719&Cisplatin@Au@MOF@MS-ICG (BCAMM), BCAMM modified with dYNH targeting peptide (BCAMMD). Scale bar: 20 µm.  Reproduced with permission from Ref. [55]