Fig. 10
From: Application of advanced biomaterials in photothermal therapy for malignant bone tumors
Schematic representation of the biomaterial design mechanism for the combination of PTT and immunotherapy. A Schematic illustration for the synthesis of GNR-PEI/cGAMP, the combination of localized tumor vaccine and anti-PD-1, the checkpoint blockade and tumor immune tolerance microenvironment reversed. B The proportion of CD8.+ T cells and MDSCs in distant tumors. Abbreviation: golden nanorod (GNR), thiolated PEI (PEI-SH), PEI conjugated GNR (GNR-PEI), cyclic dimeric guanosine monophosphate-adenosine monophosphate (cGAMP), dendritic cells (DCs), cytotoxic T lymphocytes (CTLs). Reproduced with permission from Ref. [216]