Fig. 1

Characterization of ECM and CCM components. (A) Immunofluorescence staining of major ECM proteins (blue: DAPI, green: fibronectin, red: collagen type I, collagen III, laminin). (B) Analysis of CCM for human cytokines using proteomic microarray kit. (C) Antibody array of human growth factors in the CCM. Those positive signals (B) and (C) were normalized via the dot intensity of positive control (100%). (D) The cytokines detected with a normalized intensity (> 5%) were appeared in the graph (****p < 0.0001). (E) Positive dots of growth factors with a normalized intensity (> 20%) were quantitatively marked in the graph (**** p < 0.0001)