Fig. 6

A Schematic diagram of S. boulardii bioactive material used as coating of endotracheal tube to inhibit the ability of C. albicans to infect mice. B Photos of the uncoated endotracheal tube and endotracheal tube coated with S. boulardii bioactive material. Endotracheal tube was immersed in GelMA solution containing PEO, LAP, and S. boulardii, and then illuminated by UV at Ex = 365 nm to finish photo-crosslinking. C Tissue sections of mice kidneys surgically implanted with tubes that were (a) blank or (b) coated with hydrogel, (c) coated with S. boulardii bioactive material, or (d) coated with S. boulardii (pGK1-MCP1) bioactive material for 7 days. D The capacity of C. albicans in kidney. (a), (b), (c), and (d) are the same as in (C). E Photos and F attachment tissue section of tube and tubes coated with different materials derived from mice. G Tissue sections of kidneys of mice after implantation of uncoated tube or tubes coated with different materials cultured with C. albicans for 2 h. (a) Control tube, (b) tube coated with hydrogel, (c) tube coated with S. boulardii bioactive material, and (d) tube coated with S. boulardii (pGK1-MCP1) bioactive material. Bar = 100 μm. Statistical significance was defined based on the different p-values: *p < 0.05, **p < 0.01, and ***p < 0.001