Fig. 7

In vivo therapeutic efficacy comparison of ApoLNP with different administration routes (a) During the MSC-guided ApoLNP treatment (0.15 mg/kg, based on DOX content, once per 3 days), the IVIS images of recipient mice were acquired and (b) the intratumoral fluorescent intensities were calculated. c The tumor sizes were measured for 12 days to compare the difference in therapeutic effect according to the ApoLNP administration routes, and (d) their digital images were also obtained (black dashed line = tumor) (n = 3). e Upon completing the treatment procedure, tumor tissues were collected and their H&E histology was performed. f The tumor tissues were further stained with TUNEL to determine the degree of tumor apoptosis. g The tumoral IAP expression levels depending on the ApoLNP administration routes were evaluated via western blot (n = 3). * p < 0.05, ** p < 0.01, **** p < 0.0001