Fig. 4

Ex vivo intratumoral distribution assay of MSC-guided administered LNP candidates (a) The CLSM images of tumor sections from three different regions were acquired, determining that the 10PS-treated tumor tissue expressed the highest fluorescent signals throughout all sections. b The brightest and darkest areas in the CLSM images of Sect. 2 were magnified to precisely compare the regularity of LNP distribution inside the tissues. 10PS was found to be most evenly distributed inside the tumor. c The extracted organs and tumors from all recipient mice were examined with IVIS and (d) their fluorescent intensities were quantified