Fig. 7
From: Exosome-bearing hydrogels and cardiac tissue regeneration
Exo-bearing hydrogels can be used for the induction of vascularization in ischemic changes. The angiogenic potential of Tβ4-Exos bearing GelMA/PEGDA microspheres was examined in a mouse model of MI (a-f). Using immunofluorescence staining, the capillary intensity (CD31+ vessels) was calculated in different groups including sham, infarct + PBS (PBS), GelMA/PEGDA microsphere alone (MS), Tβ4-Exos + GelMA/PEGDA microsphere (Tβ4-Exos), and Tβ4-Exo producing stem cells + GelMA/PEGDA microsphere (Tβ4-Exos + ASC) after 28 days (Scale bar: 75 μm) (a and b).The number of α-SMA+ arterioles (c and d). Cross-section of cardiac tissue and monitoring entire CD31 expression (e). The gross appurtenance of hearts after microfilling (f). White star: RCA (right coronary artery); White triangle: LCA (left anterior descending); White arrow: (the ligation of LAD). Microspheres (MS); Phosphate-buffered saline (PBS). One-way analysis of variance (ANOVA). **p < 0.01; ***p < 0.001 [135]. Copyright 2022. Bioactive Materials