Fig. 6
MWM test and hippocampal brain activity. The following groups were used: normal rats (control), rats treated with PBS injection (Sham), rats with AlCl3-induced AD (AlCl3), rats with AlCl3-induced AD treated with CLB (AlCl3 + CLB), and rats with AlCl3-induced AD treated with SHAP-CLB (AlCl3 + SHAP-CLB) (n = 6, *P < 0.05, **P < 0.01, ***P < 0.001 versus control. #P < 0.05, ##P < 0.01, ###P < 0.001 versus the AlCl3 group). Hippocampal brain activity was assessed using fMRI analysis. The intensity of brightness within the ROI on single-shot GRE-EPI images was used as a measure of brain activity (n = 6). Compared to that of the control and SHAP-CLB groups, the intensity of brightness within the ROI of the AlCl3 group was approximately 15% lower. This decrease in intensity indicates reduced brain activity in the hippocampus in the AlCl3 group