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Fig. 7 | Biomaterials Research

Fig. 7

From: GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model

Fig. 7

In vivo distribution the Bif@PAu-NPs hybrid and its anti-tumor immune response. A Fluorescence images of CT-26 tumor-bearing mice after intravenous injection of free ICG, PAu/ICG, ICG@Bif and Bif@PAu@ICG. The right panel shows in vitro fluorescence photos of isolated organs and tumors on 48 h after injection. (H: heart, Li: liver; S: spleen; Lu: lung, K: kidney, T: tumor). B Au content in tumors. C Au content in tumor and major organs of mice after Bif@PAu-NPs injection. D Percentage of mature DCs in spleen. E Percentage of mature DCs in tumor. F The ratio of CD8/CD4 in spleen. G Infrared thermography images of mice irradiated with NIR laser for 5 min. H The temperature change in each group (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). Groups. I: Control. II: Bif + NIR + GM-CSF. III: PAu-NPs + NIR + GM-CSF. IV: Bif@PAu-NPs + GM-CSF. V: Bif@PAu-NPs + NIR. VI: Bif@PAu-NPs + NIR + GM-CSF.

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Biomaterials Research

ISSN: 2055-7124

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