Fig. 6

C820 NPs sensitized cisplatin chemotherapy and inhibited recurrence. A Schematic illustration of the establishment and treatment regimen for the LoVo/CDDP tumor-bearing BALB/c nude mice model. B Body weight of tumor-bearing BALB/c nude mice (n = 5) in different groups. C Tumor volume and D representative images of the dissected tumors of different groups (n = 5). E Tumor weight and inhibition ratio of tumor-bearing BALB/c nude mice (n = 5) with different treatments. F The expression levels of GPX4 and HIF-1 protein in tumors by western blot. G Representative immunohistochemistry and immunofluorescence images of tumor sections from control and treated mice. H Schematic illustration of tumor recurrence model establishment and subsequent treatment. I and J Representative images of mice that relapse on the day and after surgery (n = 5). K Tumor weight and inhibition ratio of recurrent tumors. L Final tumor weights (n = 5). All data are shown as mean ± SD and are representative of five independent experiments; one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001