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Fig. 1 | Biomaterials Research

Fig. 1

From: Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment

Fig. 1

Characterization and intracellular uptake of C820 NPs. A Size distribution analysis and B zeta potentials of C820 NPs. C TEM image of C820 NPs. Scale bar: 200 nm. D Size distribution of C820/NPs over 4 weeks. E UV-vis absorption spectra of IR820, IR820-OH, and L820. F In vitro release profiles of CDDP from C820 NPs in PBS at pH 7.4, pH 6.5 and pH 5.0, respectively. For B, D, and F, the depicted results are mean ± SD, n = 3. G Drug loading efficiency of C820 NPs. H Infrared thermal images and temperature variations of IR820, L820, and C820 NPs in water after laser irradiation (Ctrl and IR820: 808 nm; L820 and C820 NPs: 660 nm; P = 1.0 W/cm2; irradiation time = 5 min). I Fluorescence microscopy images of C820 NPs absorbed by LoVo/CDDP at 0, 1, 2, 4, and 6 h. Scale bar: 150 μm. J Flow cytometry analysis of the time-dependent cellular absorption of C820. Data represent means ± SD (n = 3, one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001)

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Biomaterials Research

ISSN: 2055-7124

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