Fig. 12
From: mRNA nanodelivery systems: targeting strategies and administration routes
A Negatively charged phospholipids (such as BMP) aided spleen delivery of mRNA-LNPs. The fluorescein imaging of organs in vivo and liver to spleen ratio of luminescence were presented. Reproduced with permission [186]. Copyright 2022, The Royal Society of Chemistry. B Structures of ionizable lipids affected the targeted delivery of mRNA to the spleen. Functional luciferase expression results showed that biodistribution of OF-Deg-Lin FLuc mRNA LNPs was predominantly in the spleen. Reproduced with permission [189]. Copyright 2017, John Wiley and Sons. C Synthesis of fingolimod-conjugated CARTs and schematic illustration of targeted delivery of mRNA to lymphocytes in spleen. Reproduced with permission [195]. Copyright 2022, American Chemical Society