Fig. 11
From: mRNA nanodelivery systems: targeting strategies and administration routes
Schematic illustration of the microscopic anatomical structure of spleen and the journey of mRNA NPs in spleen via intravenous injection. The spleen is divided into three main areas: red pulp (RP), white pulp (WP), and marginal zone (MZ). RP is rich in macrophages, reticular cells and related reticular fibers, while the WP is involved in the proliferation of both B and T cells. The MZ comprises specialized macrophages