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Fig. 9 | Biomaterials Research

Fig. 9

From: GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances

Fig. 9

Stratified-structural hydrogel scaffold integrated with Mg ions-loaded BP nanosheets with good angiogenesis, osteogenesis and upregulation of nerve-related protein expression for promoting neuro-vascularized bone regeneration. a Schematic illustration of the bilayer hydrogel scaffold consisting of the upper (GelMA-BP@Mg) hydrogel and the bottom layer (GelMA-PEG/β-TCP) hydrogel. b Characterization of the bilayer hydrogel scaffolds. c In vitro angiogenesis evaluation of HUVECs on different hydrogel scaffolds. d Cell viability of HUVECs cultured on different hydrogels. e In vivo bone regeneration of rat calvarial defects treated with different hydrogel scaffolds. Images reproduced from [40], © 2022 Elsevier Ltd

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Biomaterials Research

ISSN: 2055-7124

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