Current aspects of small extracellular vesicles in pain process and relief

Biomaterials Research

Table 4 Modified sEVs for pain relief

Published year	Model	Resources	Effects	Modified methods	Ref.
2022	Carrageenan-induced pain	M0 macrophages	Resolve inflammatory pain	Artificial vesicles from cells	[21]
2021	IVD	NPs	Anti-catabolic and anti-inflammation	Loaded with FOXF1 by electroporation	[115]
2021	DPN	MSCs	Normalized nerve conduction velocity and compound muscle action potential	Hybrid (fusion of EVs and PpyNps-liposome by freeze-thawing)	[149]
2021	IR-induced pain	Neurons	Attenuated pain hypersensitivity	Hypoxia-precondition induced high level of miR-126-3p	[56]
2021	SNI	Neurons	Reduced neuropathic hypersensitivity	Loaded with miR-21 antagomir	[54]
2020	CFA	M2 macrophages	Increased mechanical allodynia threshold	Transfection with lentivirus-miR-23a-3p	[97]
2020	SNL	MSCs	Upregulated withdrawal threshold and latency	Combination with alginate scaffold	[172]
2017	SNI	Neurons	Attenuated neuropathic hypersensitivity	Loaded with miR-23a antagomir	[53]

NDEVs Neuron-derived EVs, SNI Spared nerve injury, CFA Complete Freund’s Adjuvant, IR Ischemia-reperfusion, SNL Spinal nerve ligation, DPN Diabetic peripheral neuropathy, PpyNps Polypyrrole nanoparticles

ISSN: 2055-7124