Fig. 5

Fabricating synthetic protocells by NISA method, and restoring calcium homeostasis in chemoresistant cancer cells. (a) Schematic illustration of synthetic protocells restoring calcium homeostasis and overcoming drug resistance. (b) Confocal images of fam-siRNA loaded synthetic protocells. Scale bar, 100 μm. (c) Confocal images reflect the calcium ion concentration in various groups. Scale bar, 100 μm. (d) Tumor volume of various groups during treatment. (e) Tumor weight from various groups after treatment. (f) Body weight from various groups during treatment. (g) Pictures of tumors harvested from the treated mice after treatment. (h) H&E, Tunnel, and Ki67 stained A549/PTX tumor slices from various groups. Scale bar, 100 μm