Table 5 List of clinically approved PEG-based adhesives (modified from ref. 22)
From: Progress of tissue adhesives based on proteins and synthetic polymers
Company name (country name) | Trade name | Components | Clinic applications | Ref. |
|---|---|---|---|---|
Focal Inc. (USA) | FocalSeal | PEG-co-poly(lactic acid) diacrylate and PEG-co-poly(trimethylene carbonate)diacrylate | Closure of visceral pleural air leaks in pulmonary resection | [133] |
Covidien (UK) | DuraSeal | PEG NHS ester and trilysine amine | Dural repair of durotomy in the spine for watertight closure | [134] |
Baxter Bio Science Inc (USA) | CoSeal | PEG NHS ester and PEG thiol | Hemostasis in vascular surgery | [135] |
Ocular Theapeutix Inc (USA) | Resure | PEG and trilysine acetate | Use for clear corneal incisions | [136] |
HyperBranch Medical Technology (USA) | OcuSeal | PEG aldehyde and cysteine-terminated lysine dendron | Protective barrier for corneal, conjunctiva, and sclera surfaces | [137] |
Covidien (UK) | SprayGel | PEG NHS ester and PEG amine | Gynecological and colorectal surgeries for adhesion barrier | [138] |
Stryker Corp.(USA) | Adherus | PEG NHS ester and hyperbranched poly(ethylene imine) | Dural repair of cerebrospinal fluid leaks for watertight closure | [139] |