Fig. 5
From: Progress of tissue adhesives based on proteins and synthetic polymers
Schematic of the mechanism of the crosslinking reaction between carboxylic acids and lysine, through activation with 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide (EDC) and N-hydroxysuccinamide (NHS). The amide bond is formed directly between the two amino acids of gelatin with no linker in between. (Adapted from Rose et al. Materials(Basel). 2014;7(4):3106–3135 [58])