Fig. 5
From: Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
Drug delivery system to improve the delivery efficacy of bioTPD. (A) A polymeric nanoparticle-mediated delivery system was used for combination therapy of phototherapy, and PROTAC-engaged immunotherapy. (B) The antibody-tethered Nano-ERASER was transported into cells (1) and subsequently released antibodies upon a high level of glutathione (GSH) (2). The antibodies primed the corresponding POI (3) and drive them for degradation through Trim-Away pathway (4). The figure was created in BioRender.com