Fig. 6
From: Reprogramming the tumor microenvironment with biotechnology
Inhibition and depletion of Tregs in TME can increase the survival rate and decrease tumor growth. a Schematic of the experimental setup to evaluate the contribution of IFN-γ to anti-tumor T cell activity in vivo. Mice bearing orthotopic glioblastoma tumors (GL261-MGH or CT2A, size -2 mm3) were treated with six doses of (i) αPD1 + αGITR, and (iv) αPD1 + αGITR + αIFN-γ (250 μg/mouse). (Reproduced with permission from [68] Copyright 2021, Nature Communication). b CTLA-4 blockade enhances CTL induction in the absence of CD25+ Tregs. CD25.− splenocytes were used to analyze the effect of CTLA-4 blockade on the induction of effector CTL in vitro (left) and in vivo (right). (Reproduced with permission from [69] Copyright 2021, Clinical Cancer Research)