Fig. 1

A Schematic illustration of anti-Thy 1.1 or anti-CD45 conjugated liposome for T cell targeting. B Mean fluorescence of pmel-1 Thy1.1+ T-cells after co-incubation with anti-CD45-liposome or anti-Thy1.1-liposome analyzed by flow cytometry. C Schematic illustration of the process in which anti-CD4 Ab functionalized lipid NPs were prepared for siRNA delivery to T cell. D Percentage of CD45 silencing CD4+ T cells in blood 5 days after intravenous injection into mice with saline (mock), LNPs (siCD45) tLNPs (siCD45), isoLNPs (siCD45), or tLNPs (siLuc); data represent mean ± SD, n = 5, **p < 0.005. A, B Reprinted from [19], copyright permission by American Chemical Society 2017. C, D Reprinted from [20], copyright permission by American Chemical Society 2015