From: Liposomal delivery systems for intestinal lymphatic drug transport
Method | Concept | Advantages | Disadvantages | References |
---|---|---|---|---|
Postprandial state (diet-derived) | Drugs are co-administered with food. | Chylomicrons are synthesized more than those of treating any other methods. | Uncontrollable method | |
Lipidic prodrugs | Drugs are covalently bound to a lipid moiety (fatty acid, glyceride, phospholipid). | Through covalent bonding with lipids, lipophilicity of drugs can be increased. | - Pharmaceutically inert - Safety and toxicity problems | |
Lipid-based nanoparticles (formulation-derived) | Administration of a single capsule of long-chain lipid can stimulate significant lymphatic transport of drugs. - Solid lipid nanoparticles - Self-nanoemulsifying drug delivery systems - Emulsion - Liposomes | - Effective carriers for drugs - Stimulators of chylomicron production | The effect of the formulation on drug absorption and lymphatic transport is less clear. |